Single-Camera Multiparametric Imaging in Cardiac Electrophysiology
The field of cardiac electrophysiological imaging has advanced tremendously in the past three decades with developments in fluorescent dyes, photodetectors, optical filters, illumination sources, computers and electronics. Here, we describe a scalable multiparametric imaging system and its application to low-light 2D tissue preparations: thin ventricular tissue slices and human iPS cell-derived cardiomyocyte monolayers. The three key electrophysiological parameters measured were transmembrane voltage, intracellular calcium concentration and excitation wave propagation. Such approaches may soon lead to high-throughput drug testing and patient-specific investigation of cardiac diseases.
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