UK university buys two Titan Krios TEMs


Rebecca Pool

Tuesday, November 10, 2015 - 15:00
The Titan Krios is the most powerful high-resolution electron microscope for 2D and 3D characterisation of protein structures and protein complexes.
“Currently, there are only two Titan Krios systems in the UK, with a couple more on the way," highlights Professor Neil Ranson, School of Molecular and Cellular Biology at Leeds.
"There is an insatiable demand for time on microscopes with these capabilities, and access is very difficult to come by," he adds. "We are very excited to be able to purchase two Titan Krios systems with direct electron detecting cameras; they will help to establish Leeds as one of the leading centers for cryo-TEM research in the world.”
The two Krios systems were purchased as part of a £17M investment from the University’s strategic reserves, and with help from a £1M award from the Wellcome Trust to support biomedical discovery.
The installation of the systems will begin in March 2016. 
“Cryo-TEM is undergoing unprecedented growth because improvements in microscopes and detectors now enable close-to-atomic resolution structures for many biological systems,” says Professor Sheena Radford, Astbury Professor of Biophysics and Director of the Astbury Centre.
“However the full potential of cryo-EM will come as a result of the synergy with other technologies, such as X-ray diffraction (XRD) and nuclear magnetic resonance spectrometry (NMR)," she adds. "The University of Leeds is also acquiring a new, state-of-the-art 950MHz NMR instrument dedicated to biological research in the Astbury Centre.”
And as Peter Fruhstorfer, FEI’s Vice President and General Manager of the Life Sciences business, adds: “The ability to purchase two systems is significant and will give the University the flexibility to conduct not only its own structural biology research, but also to build collaborations with researchers at other universities and institutions.”
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