Biologists showcase stunning lung image

Editorial

Rebecca Pool

Thursday, March 7, 2019 - 14:30
Image: Fluorescence microscopy image reveals muscle actin.
 
The Baylor College of Medicine, Texas, has unveiled its stunning image of the month; the trachea and vasculature of a mouse lung.
 
The colourised fluorescence microscopy image reveals muscle actin (fluorescent teal), defining smooth muscle cells in the trachea and arteries.
 
Captured by Dr Joshua Wythe from the Baylor College of Medicine, and colleagues from his laboratory and the Optical Imaging and Vital Microscopy Core at the College, the image forms part of research to better understand vascular and cardiac development, as well as cardiovascular disease.
 
Smooth muscle labelling of trachea and arteries in a mouse lung. [Optical Imaging and Vital Microscopy Core/research from the Wythe lab].
 
In their vascular research, Wythe and colleagues are trying to understand how the identities of arterial and venous endothelial cells are maintained in the developing vertebrate embryo.
 
Meanwhile, cardiac-related research focuses on understanding how cell fates are specified in the embryonic mouse heart, both in normal and developmentally compromised genetic backgrounds.
 
Cardiovascular disease research focuses on congenital cardiac malformations including septation defects.
 
The Optical Imaging and Vital Microscopy Core is dedicated to 3D imaging of complex systems and high-resolution investigations of living cells.
 
The facility offers live intravital imaging that allows researchers to observe cells in their native environment or within a 3D construct that mimics the microenvironment. 
 
Learn more here.
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